Article
A humanized mouse model for a common beta0-thalassemia mutation.
Genomics - 1 Apr 2005
Jamsai Duangporn, Zaibak Faten, Khongnium Wantana, Vadolas Jim, Voullaire Lucille, Fowler Kerry J, Gazeas Sophie, Fucharoen Suthat, Williamson Robert, Ioannou Panayiotis A
Abstract excerpt
Accurate animal models that recapitulate the phenotype and genotype of patients with beta-thalassemia would enable the development of a range of possible therapeutic approaches. Here we report the generation of a mouse model carrying the codons 41-42 (-TTCT) beta-thalassemia mutation in the intact human beta-globin locus. This mutation accounts for approximately 40% of beta-thalassemia mutations in southern China...
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