Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Knockout-Transgenic Mouse Model of Sickle Cell Disease

31 Oct 1997

Abstract excerpt

When transgenic mice that expressed human sickle hemoglobin were mated with mice having knockout mutations of the mouse alpha- and beta-globin genes, animals were produced that synthesized only human hemoglobin in adult red blood cells. Similar to many human patients with sickle cell disease, the mice developed a severe hemolytic anemia and extensive organ pathology. Numerous sickled erythrocytes were observed in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hemoglobinopathies and Related Disorders
Share to Iron Metabolism and Disorders
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9346487
DOI: 10.1126/science.278.5339.873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Knockout-Transgenic Mouse Model of Sickle Cell DiseasePMID 9346487Read ↗

Transgenic Knockout Mice with Exclusively Human Sickle Hemoglobin and Sickle Cell DiseaseSemantic proximity Read ↗

Mouse models of sickle cell disease: Imperfect and yet very informativeSemantic proximity Read ↗

A mouse model for beta 0-thalassemia.Semantic proximity Read ↗

Lessons from transgenic mouse lines expressing sickle hemoglobin.Semantic proximity Read ↗

Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells.Semantic proximity Read ↗

Transgenic mice and hemoglobinopathies.Semantic proximity Read ↗

Towards a transgenic mouse model of sickle cell disease: hemoglobin SAD.Semantic proximity Read ↗

Pathology of Berkeley sickle cell mice: similarities and differences with human sickle cell disease.Semantic proximity Read ↗

A mouse model for hemoglobin SC disease recapitulates characteristic human pathologies.Semantic proximity Read ↗

Preclinical transfusion-dependent humanized mouse model of beta thalassemia major.Semantic proximity Read ↗

Investigational curative gene therapy approaches to sickle cell diseaseSemantic proximity Read ↗

Phenotypic Characterization the Townes Sickle MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.