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Article

Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway.

Science (New York, N.Y.) - 20 Sept 1996

Kim T K, Maniatis T

Abstract excerpt

STAT proteins (signal transducers and activators of transcription) are latent cytoplasmic transcription factors that are phosphorylated by Janus kinases in response to cytokines. Phosphorylated STAT proteins translocate to the nucleus, where they transiently turn on specific sets of cytokine-inducible genes. The mechanism that controls the amounts of activated STAT proteins is not understood. STAT1 proteins...

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Identifiers

PMID: 8781235
DOI: 10.1126/science.273.5282.1717

Genes

STAT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 9 closest

Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway.PMID 8781235Read ↗

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.Semantic proximity Read ↗

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PIAS proteins promote SUMO-1 conjugation to STAT1.Semantic proximity Read ↗

PML positively regulates interferon gamma signalingSemantic proximity Read ↗

Regulation of Stat1 protein expression by phenylalanine 172 in the coiled-coil domain.Semantic proximity Read ↗

Recruitment of Stat4 to the Human Interferon-α/β Receptor Requires Activated Stat2Semantic proximity Read ↗

Mumps virus V protein antagonizes interferon without the complete degradation of STAT1.Semantic proximity Read ↗

Suppressor of cytokine signaling 1 (SOCS1) limits NFκB signaling by decreasing p65 stability within the cell nucleusSemantic proximity Read ↗

Positive effects of SH2 domain-containing tyrosine phosphatase SHP-1 on epidermal growth factor- and interferon-gamma-stimulated activation of STAT transcription factors in HeLa cells.Semantic proximity Read ↗

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