Article
The Saccharomyces cerevisiae IMP2 gene encodes a transcriptional activator that mediates protection against DNA damage caused by bleomycin and other oxidants.
Molecular and cellular biology - 1 May 1996
Masson J Y, Ramotar D
Abstract excerpt
Bleomycin belongs to a class of antitumor drugs that damage cellular DNA through the production of free radicals. The molecular basis by which eukaryotic cells provide resistance to the lethal effects of bleomycin is not clear. Using the yeast Saccharomyces cerevisiae as a model with which to stu...
Topics
- Bacterial Proteins
- Base Sequence
- Bleomycin
- Cloning, Molecular
- DNA Damage
- DNA Primers
- Endopeptidases
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Genetic Complementation Test
- Genotype
- Kinetics
- Mitochondrial Proteins
- Molecular Sequence Data
- Nuclear Proteins
- Oligodeoxyribonucleotides
- Oxidants
- Promoter Regions, Genetic