Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Saccharomyces cerevisiae IMP2 gene encodes a transcriptional activator that mediates protection against DNA damage caused by bleomycin and other oxidants.

Molecular and cellular biology - 1 May 1996

Masson J Y, Ramotar D

Abstract excerpt

Bleomycin belongs to a class of antitumor drugs that damage cellular DNA through the production of free radicals. The molecular basis by which eukaryotic cells provide resistance to the lethal effects of bleomycin is not clear. Using the yeast Saccharomyces cerevisiae as a model with which to study the effect of bleomycin damage on cellular DNA, we isolated several mutants that display hypersensitivity to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Base Sequence
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Primers

Share to Genotype

Share to Kinetics

Share to Molecular Sequence Data

Share to Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 8628275
DOI: 10.1128/MCB.16.5.2091
PMCID: PMC231196

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Saccharomyces cerevisiae IMP2 gene encodes a transcriptional activator that mediates protection against DNA damage caused by bleomycin and other oxidants.PMID 8628275Read ↗

Isolation and characterization of Saccharomyces cerevisiae mutants with enhanced resistance to the anticancer drug bleomycin.Semantic proximity Read ↗

An allele of the yeast RPB7 gene, encoding an essential subunit of RNA polymerase II, reduces cellular resistance to the antitumor drug bleomycin.Semantic proximity Read ↗

A Saccharomyces cerevisiae mutant defines a new locus essential for resistance to the antitumour drug bleomycin.Semantic proximity Read ↗

The transcriptional activator Imp2p maintains ion homeostasis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Disruption of the Saccharomyces cerevisiae cell-wall pathway gene SLG1 causes hypersensitivity to the antitumor drug bleomycin.Semantic proximity Read ↗

Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts.Semantic proximity Read ↗

Overexpression of genes involved in vesicular trafficking to the vacuole defends against lethal effects of oxidative damage.Semantic proximity Read ↗

A Saccharomyces cerevisiae phleomycin-sensitive mutant, ph140, is defective in the RAD6 DNA repair gene.Semantic proximity Read ↗

Isolation and characterization of mAMSA-hypersensitive mutants. Cytotoxicity of Top2 covalent complexes containing DNA single strand breaks.Semantic proximity Read ↗

IMP2, a nuclear gene controlling the mitochondrial dependence of galactose, maltose and raffinose utilization in Saccharomyces cerevisiae.Semantic proximity Read ↗

Functional mitochondria are essential for Saccharomyces cerevisiae cellular resistance to bleomycin.Semantic proximity Read ↗

The protein degradation response of Saccharomyces cerevisiae to classical DNA-damaging agents.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.