Response of human platelets to activating monoclonal antibodies: importance of Fc gamma RII (CD32) phenotype and level of expression.

Article

Response of human platelets to activating monoclonal antibodies: importance of Fc gamma RII (CD32) phenotype and level of expression.

Blood - 1 Nov 1992

Tomiyama Y, Kunicki T J, Zipf T F, Ford S B, Aster R H

Abstract excerpt

Certain monoclonal antibodies (MoAbs) specific for platelet membrane glycoproteins are known to be capable of activating platelets, and it is generally thought that platelets from normal subjects are equally susceptible to stimulation by such MoAbs. We found that platelets from 20 normal donors v...

Topics

Animals
Antibodies, Monoclonal
Binding Sites, Antibody
Blood Platelets
Humans
Immunoglobulin Fab Fragments
Immunoglobulin G
Mice
Phenotype
Platelet Aggregation
Receptors, IgG
Serotonin

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