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Article

Haemophilia A: mutation type determines risk of inhibitor formation.

Thrombosis and haemostasis - 1 Dec 1995

Schwaab R, Brackmann H H, Meyer C, Seehafer J, Kirchgesser M, Haack A, Olek K, Tuddenham E G, Oldenburg J

Abstract excerpt

The formation of factor VIII antibodies is a major problem for replacement therapy of haemophilia A patients. Antibodies occur in 5-30% of patients with severe haemophilia A. The reason for antibody formation is still unknown. In this study we correlate for the first time different factor VIII ge...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8772209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8772209-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The incidence of inhibitor development according to specific mutations--and treatment?Semantic proximity Read ↗

Influence of the type of F8 gene mutation on inhibitor development in a single centre cohort of severe haemophilia A patients.Semantic proximity Read ↗

Factor VIII genotype and inhibitor development in patients with haemophilia A: highest risk in patients with splice site mutations.Semantic proximity Read ↗

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