Article
Factor VIII mutations and inhibitor formation in a southern Brazilian population.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Mar 2014
Rosset Clévia, Gorziza Roberta P, Botton Mariana R, Salzano Francisco M, Bandinelli Eliane
Abstract excerpt
A total of 110 patients with severe (n = 43), moderate (n = 15) or mild (n = 52) haemophilia A were studied in relation to their F8 gene mutation and inhibitor status. Nineteen percentage of them had anti-factor VIII antibodies. Significant heterogeneity in inhibitor prevalence considering the location of the patients' mutation was found, with higher frequencies in carriers of mutations in the C1 and B domains....
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