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HLA genotype of patients with severe haemophilia A due to intron 22 inversion with and without inhibitors of factor VIII.

Thrombosis and haemostasis - 1 Feb 1997

Oldenburg J, Picard J K, Schwaab R, Brackmann H H, Tuddenham E G, Simpson E

Abstract excerpt

Molecular genetic studies have shown that development of antibodies to factor VIII (inhibitors) occurs most frequently in patients with severe haemophilia due to major gene lesions including inversions, stop codons and large deletions. Previous studies of HLA type were performed on inhibitor and...

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PMID: 9157573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9157573-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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HLA genotype of patients with severe haemophilia A due to intron 22 inversion with and without inhibitors of factor VIII.PMID 9157573Read ↗

Prevalence of the intron 22 inversion of the factor VIII gene and inhibitor development in Polish patients with severe hemophilia A.Semantic proximity Read ↗

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Impact of HLA alleles and cytokine polymorphisms on inhibitors development in children with severe haemophilia A.Semantic proximity Read ↗

Factor VIII inhibitor development in Egyptian hemophilia patients: does intron 22 inversion mutation play a role?Semantic proximity Read ↗

HLA class II profile: a weak determinant of factor VIII inhibitor development in severe haemophilia A. UKHCDO Inhibitor Working Party.Semantic proximity Read ↗

Human leukocyte antigen alleles associated with inhibitor development in severe hemophilia A: analysis of the "My Life, Our Future" hemophilia A cohort.Semantic proximity Read ↗

Haemophilia A: mutation type determines risk of inhibitor formation.Semantic proximity Read ↗

Factor VIII gene inversions in severe hemophilia A patients.Semantic proximity Read ↗

Frequency of intron 1 and 22 inversions of <i>factor VIII</i> gene in Mexican patients with severe hemophilia ASemantic proximity Read ↗

Ethnicity-specific impact of HLA I/II genotypes on the risk of inhibitor development: data from Korean patients with severe hemophilia A.Semantic proximity Read ↗

Inversions disrupting the factor VIII gene are a common cause of severe haemophilia A.Semantic proximity Read ↗

Relationship between mutations in severe hemophilia A and risk of inhibitor development: A large single-center study.Semantic proximity Read ↗

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