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Article

Factor VIII inhibitor development in Egyptian hemophilia patients: does intron 22 inversion mutation play a role?

Italian journal of pediatrics - 14 Sept 2020

Sherief Laila M, Gaber Osama A, Youssef Hala Mosaad, Sherbiny Hanan S, Mokhtar Wesam A, Ali Asmaa A A, Kamal Naglaa M, Abdel Maksoud Yehia H

Abstract excerpt

BACKGROUND: Hemophilia A (HA) is an X-linked recessive bleeding disorder characterized by qualitative and quantitative deficiency of factor VIII (FVIII). The development of inhibitor antibodies against FVIII is the most challenging complication of treatment. Mutations in the FVIII gene is one of the genetic factors that leads to development of FVIII inhibitors especially intron 22 inversion (Inv22). OBJECTIVES:...

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PMID: 32928254
DOI: 10.1186/s13052-020-00878-5
PMCID: PMC7488666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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