Genetic risk factors for inhibitors to factors VIII and IX.

Abstract excerpt

The formation of alloantibodies against factor VIII (FVIII) or factor IX (FIX) is the most severe complication of replacement therapy in patients with haemophilia. In the last decade, genetic factors have been shown to constitute a decisive risk determinant for the development of inhibitors. In severe haemophilia A and B, mutations that result in an absent or truncated FVIII/FIX protein are associated with a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blood Coagulation Factor Inhibitors
• Share to Cytokines
• Share to Factor IX