Mutation, selection, and memory in B lymphocytes of exothermic vertebrates.

Abstract excerpt

Unlike mammals, cold-blooded vertebrates produce antibodies of low heterogeneity that show little increase in binding affinity with time after immunization. In secondary responses, antibody titers and affinities are often little, if any, higher than in primary responses. That is, specificity, diversity, and memory--the hallmarks of the immune system--are rather meager in the humoral immune responses of exothermic...

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