Article
B-cell development in the amphibian Xenopus.
Immunological reviews - 1 Jun 2000
Du Pasquier L, Robert J, Courtet M, Mussmann R
Abstract excerpt
The amphibian Xenopus and mammals have similar organization and usage of their immunoglobulin gene loci with combinatorial joining of V, D and J elements. The differences in B-cell development between mammals and this amphibian are due to major differences in developmental kinetics, cell number and lymphoid organ architecture. Unlike mammals, the immune system of Xenopus develops early under pressure to develop...
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