Article
Increased PTHRP production by a tyrosine kinase oncogene, Tpr-Met: role of the Ras signaling pathway.
The American journal of physiology - 1 Aug 1996
Aklilu F, Park M, Goltzman D, Rabbani S A
Abstract excerpt
We have used the Tpr-Met oncogene as a model to examine signaling pathways of growth factors and tyrosine kinase oncogenes that can increase parathyroid hormone-related peptide (PTHRP) production. PTHRP production in Tpr-Met transfected cells, when assessed by Northern blot analysis and radioimmu...
Topics
- 1-Phosphatidylinositol 4-Kinase
- Androstadienes
- Cell Division
- Cell Line
- Drug Stability
- Enzyme Inhibitors
- Gene Expression
- Genes, ras
- Lovastatin
- Mutation
- Oncogenes
- Parathyroid Hormone-Related Protein
- Phosphotransferases (Alcohol Group Acceptor)
- Protein Biosynthesis
- Protein-Tyrosine Kinases
- Proteins
- RNA, Messenger
- Signal Transduction