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Article

Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2.

Oncogene - 13 Feb 1997

Besser D, Bardelli A, Didichenko S, Thelen M, Comoglio P M, Ponzetto C, Nagamine Y

Abstract excerpt

The oncogene Tpr-Met is a constitutively active form of the hepatocyte growth factor/scatter factor (HGF/SF) receptor Met. It comprises the intracellular moiety of Met linked to the dimerization domain of the nuclear envelope protein Tpr, thus functioning as a constitutively activated Met. HGF/SF...

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Source

Identifiers

PMID: 9038378
DOI: 10.1038/sj.onc.1200879

Genes

HGF
GRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9038378-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2.PMID 9038378Read ↗

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The roles of hepatocyte growth factor/scatter factor and met receptor in human cancers (Review).Semantic proximity Read ↗

Activation of the JNK pathway is essential for transformation by the Met oncogene.Semantic proximity Read ↗

STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family.Semantic proximity Read ↗

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HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro.Semantic proximity Read ↗

Combined signaling through ERK, PI3K/AKT, and RAC1/p38 is required for met-triggered cortical neuron migration.Semantic proximity Read ↗

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