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Article

Role of mitogen-activated protein kinases in the induction of parathyroid hormone-related peptide.

Cancer research - 15 Mar 2000

Aklilu F, Gladu J, Goltzman D, Rabbani S A

Abstract excerpt

Tumor production of parathyroid hormone-related protein (PTHRP) is responsible for most cases of hypercalcemia of malignancy. The transplantable rat Leydig tumor H-500 is known to cause hypercalcemia in rats by the release of abundant PTHRP and to closely reproduce the human syndrome. We have demonstrated recently that Ras oncogene can stimulate PTHRP gene expression in Fr3T3 fibroblasts in vitro and cause...

Topics

Animals
Antineoplastic Agents
Calcium
Cycloheximide
Dose-Response Relationship, Drug
Flavonoids
Gene Expression Regulation
JNK Mitogen-Activated Protein Kinases
Lovastatin
Male
Methionine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitogen-Activated Protein Kinase Kinases

Mitogen-Activated Protein Kinases

Mutation

Neoplasms, Experimental

Parathyroid Hormone-Related Protein

Proteins

Proto-Oncogene Proteins c-raf

Source

Identifiers

PMID: 10749150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Role of mitogen-activated protein kinases in the induction of parathyroid hormone-related peptide.PMID 10749150Read ↗

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Neoplastic transformation of normal rat embryo fibroblasts by a mutated p53 and an activated ras oncogene induces parathyroid hormone-related peptide gene expression and causes hypercalcemia in nude mice.Semantic proximity Read ↗

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