Article
Parathyroid hormone related protein (PTHrP) inhibits TNFalpha-induced apoptosis by blocking the extrinsic and intrinsic pathways.
Journal of cellular physiology - 1 Feb 2007
Okoumassoun Liliane, Averill-Bates Diana, Denizeau Francine, Henderson Janet E
Abstract excerpt
Parathyroid hormone related protein (PTHrP) is expressed at low levels in many fetal and adult tissues where it plays a central role in regulating cell proliferation, cell death, and tissue homeostasis. In vivo and in vitro, PTHrP has been shown to promote the survival of a variety of cells by regulating expression of the anti-apoptotic protein Bcl2. Additional work has shown that intra-nuclear accumulation of...
Topics
- Active Transport, Cell Nucleus
- Animals
- Apoptosis
- Apoptosis Regulatory Proteins
- BH3 Interacting Domain Death Agonist Protein
- Caspase 8
- Cells, Cultured
- Humans
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mitochondrial Membranes
- Mutation
- Parathyroid Hormone-Related Protein