Article
Parathyroid hormone-related protein increases cAMP production in mammary epithelial cells.
The American journal of physiology - 1 Mar 1993
Ferrari S, Rizzoli R, Chaponnier C, Gabbiani G, Bonjour J P
Abstract excerpt
Parathyroid hormone-related protein (PTHrP) is a major cause of malignant hypercalcemia but has been found in many nontumoral tissues as well. Thus it is produced by the mammary gland during lactation and released into milk. Whether PTHrP directly affects breast tissue is however not known. We investigated the effects of PTHrP on adenosine 3',5'-cyclic monophosphate (cAMP) production in primary cultures of...
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