Article
Blood pressure and fluid-electrolyte balance in mice with reduced or absent ANP.
The American journal of physiology - 1 Jul 1996
John S W, Veress A T, Honrath U, Chong C K, Peng L, Smithies O, Sonnenberg H
Abstract excerpt
Atrial natriuretic peptide (ANP)-gene knockout mice of three genotypes (+/+, +/-, and -/-) were maintained on a low-salt diet (0.008% NaCl). They were then fed either the same low-salt diet or a high-salt diet (8% NaCl) for 1 wk. No differences were found among genotypes in daily food and water intakes or in urinary volume and electrolyte excretions. Arterial blood pressures measured in anesthetized animals at...
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