Article
Dietary salt supplementation selectively downregulates NPR-C receptor expression in kidney independently of ANP.
American journal of physiology. Renal physiology - 1 Feb 2002
Sun Ju-Zhong, Chen Shi-Juan, Majid-Hasan Erum, Oparil Suzanne, Chen Yiu-Fai
Abstract excerpt
Atrial natriuretic peptide (ANP) has negative modulatory effects on a variety of pathophysiological mechanisms; i.e., it inhibits hypoxia-induced pulmonary vasoconstriction and vascular remodeling and facilitates natriuresis and vasorelaxation in NaCl-supplemented subjects. We have previously demonstrated organ-selective potentiation of ANP in the pulmonary circulation of hypoxia-adapted animals by local...
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