Article
Increased blood pressure and loss of anp-induced natriuresis in mice lacking DARPP-32 gene.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Aug 2001
Eklöf A C, Holtbäck U, Svennilson J, Fienberg A, Greengard P, Aperia A
Abstract excerpt
Atrial natriuretic peptide (ANP) is an important regulator of sodium metabolism and indirectly of blood pressure. Evidence has accumulated that ANP regulates sodium metabolism through a cascade of steps involving an increase in the level of cGMP, activation of cGMP-dependent protein kinase (PKG), and inhibition of renal tubular Na+, K+-ATPase activity. One of the major substrates for PKG is DARPP-32. In the...
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