Article
Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension.
Science (New York, N.Y.) - 3 Feb 1995
John S W, Krege J H, Oliver P M, Hagaman J R, Hodgin J B, Pang S C, Flynn T G, Smithies O
Abstract excerpt
To determine if defects in the atrial natriuretic peptide (ANP) system can cause hypertension, mice were generated with a disruption of the proANP gene. Homozygous mutants had no circulating or atrial ANP, and their blood pressures were elevated by 8 to 23 millimeters of mercury when they were fe...
Topics
- Animals
- Atrial Natriuretic Factor
- Blood Pressure
- Crosses, Genetic
- Female
- Gene Targeting
- Genotype
- Heart Atria
- Heterozygote
- Homozygote
- Hypertension
- Male
- Mice
- Mice, Inbred C57BL
- Protein Precursors
- Sodium, Dietary