Article
Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension.
Science (New York, N.Y.) - 3 Feb 1995
John S W, Krege J H, Oliver P M, Hagaman J R, Hodgin J B, Pang S C, Flynn T G, Smithies O
Abstract excerpt
To determine if defects in the atrial natriuretic peptide (ANP) system can cause hypertension, mice were generated with a disruption of the proANP gene. Homozygous mutants had no circulating or atrial ANP, and their blood pressures were elevated by 8 to 23 millimeters of mercury when they were fed standard (0.5 percent sodium chloride) and intermediate (2 percent sodium chloride) salt diets. On standard salt...
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