Article
Loss of heterozygosity on chromosome 1 in human hepatoblastoma.
International journal of cancer - 7 Aug 1996
Kraus J A, Albrecht S, Wiestler O D, von Schweinitz D, Pietsch T
Abstract excerpt
In previous studies we have found loss of heterozygosity (LOH) on chromosome arm 11p in 33% of hepatoblastomas (HBs). In addition, cytogenetic studies have revealed aberrations of chromosome arm 1p in single cases. Therefore, we have used the PCR to amplify 10 microsatellites on the short arm and 7 microsatellites on the long arm of chromosome I to assess allelic loss in 32 cases of HB. LOH on chromosome I was...
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