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Article

Rare allelic imbalances, but no mutations of the PRDX1 gene in human hepatocellular carcinomas.

Journal of clinical pathology - 1 Nov 2005

Gisin J, Perren A, Bawohl M, Jochum W

Abstract excerpt

Allelic losses on chromosome 1p are frequent in hepatocellular carcinoma (HCC), suggesting the presence of a tumour suppressor gene in this region. The gene for peroxiredoxin 1 (PRDX1), an antioxidant enzyme, has been mapped to 1p34.1. Mice lacking PRDX1 develop HCC with high frequency. Because oxidative stress has been implicated in the pathogenesis of HCC, this study was designed to determine whether the PRDX1...

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Share to Allelic Imbalance
Share to Carcinoma, Hepatocellular
Share to Chromosomes, Human, Pair 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Liver Neoplasms

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Source

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Identifiers

PMID: 16254121
DOI: 10.1136/jcp.2004.024679
PMCID: PMC1770774

Genes

PRDX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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