p53 mutation, allele loss on chromosome 17p, and DNA content in ovarian carcinoma.

doi:10.1002/(SICI)1096-9896(199606)179:2<177::AID-PATH561>3.0.CO;2-2

Back to search

Article

p53 mutation, allele loss on chromosome 17p, and DNA content in ovarian carcinoma.

The Journal of pathology - 1 Jun 1996

McManus D T, Murphy M, Arthur K, Hamilton P W, Russell S E, Toner P G

Abstract excerpt

The aim of this investigation was to explore the relationships between p53 mutation, DNA aneuploidy, 17p deletions, and clinical stage in ovarian cancer. Nuclear suspensions were obtained by tissue disaggregation, stained with propidium iodide, and analysed on a Coulter EPICS Elite flow cytometer...

Topics

Alleles
Base Sequence
Chromosome Deletion
Chromosomes, Human, Pair 17
DNA, Neoplasm
Female
Flow Cytometry
Genes, p53
Heterozygote
Humans
Molecular Sequence Data
Mutation
Ovarian Neoplasms
Ploidies
Polymerase Chain Reaction

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.