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Article

Pathogenicity of thermolabile methylenetetrahydrofolate reductase for vascular dementia.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2000

Yoo J H, Choi G D, Kang S S

Abstract excerpt

Although the major biochemical abnormality due to methylenetetrahydrofolate reductase (MTHFR) deficiency is hyperhomocyst(e)inemia, its pathogenicity appears to involve more than homocysteine toxicity. In patients with severe MTHFR deficiency, a metabolite(s) other than hyperhomocyst(e)inemia also appears to be associated with its clinical manifestation in cerebrovascular disease. To elucidate the specific role...

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Source

Identifiers

PMID: 10938012
DOI: 10.1161/01.atv.20.8.1921

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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