Article
Activated human T cells express a ligand for the human B cell-associated antigen CD40 which participates in T cell-dependent activation of B lymphocytes.
European journal of immunology - 1 Oct 1992
Lane P, Traunecker A, Hubele S, Inui S, Lanzavecchia A, Gray D
Abstract excerpt
To identify the ligand for the B cell-associated antigen CD40, we constructed a chimeric immunoglobulin molecule where the extracellular portion of the CD40 protein replaced the normal immunoglobulin variable region. No binding was detected on resting peripheral blood T cells. However, following...
Topics
- Adult
- Antigens, CD
- Antigens, Differentiation, B-Lymphocyte
- B-Lymphocytes
- Base Sequence
- CD3 Complex
- CD40 Antigens
- Humans
- In Vitro Techniques
- Lymphocyte Activation
- Molecular Sequence Data
- Molecular Weight
- Phenotype
- Precipitin Tests
- T-Lymphocytes