Article
Coactivation with anti-CD28 monoclonal antibody enhances anti-CD3 monoclonal antibody-induced proliferation and IL-2 synthesis in T cells from autologous bone marrow transplant recipients.
Bone marrow transplantation - 1 Dec 1993
Lum L G, Joshi I D, Galoforo S C, Abella E, Karanes C, Ratanatharathorn V, Schultz K R, Uberti J P, Sensenbrenner L L, Ledbetter J A
Abstract excerpt
Recent studies show that costimulation of T cells with anti-CD28 Mab (anti-CD28) enhances anti-CD3 Mab (anti-CD3)-induced proliferative responses and cytokine production. This study determines if coactivation with anti-CD3 and anti-CD28 corrects defects in proliferation and IL-2 secretion in peripheral blood lymphocytes (PBL) from bone marrow transplant (BMT) recipients. PBL or T cells from 5 of 16 autologous and...
Topics
- Adolescent
- Adult
- Antibodies, Monoclonal
- Bone Marrow Transplantation
- CD28 Antigens
- CD3 Complex
- Humans
- In Vitro Techniques
- Interleukin-2
- Lymphocyte Activation