Characterization of the Endothelial Cell Cytoskeleton following HLA Class I Ligation

Abstract excerpt

BACKGROUND: Vascular endothelial cells (ECs) are a target of antibody-mediated allograft rejection. In vitro, when the HLA class I molecules on the surface of ECs are ligated by anti-HLA class I antibodies, cell proliferation and survival pathways are activated and this is thought to contribute to the development of antibody-mediated rejection. Crosslinking of HLA class I molecules by anti-HLA antibodies also...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Angiogenesis and VEGF in Cancer
• Share to Cell Adhesion Molecules Research
• Share to Monoclonal and Polyclonal Antibodies Research