Article
[The karyotypic variability of Chinese hamster CHLV-79 RJK cells characterized by multiple drug resistance resulting from the amplification of the mdr gene family].
Tsitologiia - 1 Jan 1996
Grinchuk T M, Lipskaia L A, Artsybasheva I V, Sorokina E A, Pan'shina Iu T, Ignatova T N
Abstract excerpt
Variability in karyotype structure of Chinese hamster lung V-79 RJK cells and of their six cell sublines, selected for increasing concentrations of ethidium bromide (EB), was investigated in addition to the number of mdr gene copies in cells, both EB sensitive and resistant. It is shown that EB resistant cells exhibit cross-resistance to different drugs resulting from mdr genes amplification. Southern DNA blot...
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