Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine beta-hydroxylase gene.

doi:10.1046/j.1471-4159.1998.71051813.x

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Article

Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine beta-hydroxylase gene.

Journal of neurochemistry - 1 Nov 1998

Yang C, Kim H S, Seo H, Kim C H, Brunet J F, Kim K S

Abstract excerpt

Recently, a murine paired-like homeobox gene, Phox2a, has been identified whose product is critical for the development of several major noradrenergic neuron populations, including the locus coeruleus. In noradrenergic neurons, dopamine beta-hydroxylase (DBH) is a hallmark protein and catalyzes t...

Topics

Animals
Base Sequence
Binding Sites
Dopamine beta-Hydroxylase
Homeodomain Proteins
Humans
Mice
Molecular Sequence Data
Mutation
Nerve Tissue Proteins
Neurons
Norepinephrine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Rats

Transcription Factors

Transcription, Genetic

Transcriptional Activation

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9798905
DOI: 10.1046/j.1471-4159.1998.71051813.x

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9798905-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine beta-hydroxylase gene.PMID 9798905Read ↗

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