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Article

Assessing genetic-based therapies for AIDS using the simian immunodeficiency virus.

Journal of medical primatology - 1 May 1995

Endres C L, Bergquam E, Axthelm M K, Wong S W

Abstract excerpt

A plasmid encoding the full-length infectious molecular proviral clone of SIVmac239 was generated. Virus derived from cells transfected with this clone replicated to high levels and was cytopathic for some transformed human CD4+ cell lines and primary rhesus macaque peripheral blood mononuclear cells. Since replication of SIV requires the functional expression of the viral encoded rev protein, transient...

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Identifiers

PMID: 8751053
DOI: 10.1111/j.1600-0684.1995.tb00159.x

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