Article
Assessing genetic-based therapies for AIDS using the simian immunodeficiency virus.
Journal of medical primatology - 1 May 1995
Endres C L, Bergquam E, Axthelm M K, Wong S W
Abstract excerpt
A plasmid encoding the full-length infectious molecular proviral clone of SIVmac239 was generated. Virus derived from cells transfected with this clone replicated to high levels and was cytopathic for some transformed human CD4+ cell lines and primary rhesus macaque peripheral blood mononuclear c...
Topics
- Animals
- CD4-Positive T-Lymphocytes
- Cell Line, Transformed
- Cloning, Molecular
- Gene Transfer Techniques
- Genes, rev
- Leukocytes, Mononuclear
- Macaca mulatta
- Mutation
- Plasmids
- Proviruses
- Simian Immunodeficiency Virus
- Time Factors
- Transfection
- Virus Replication