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Article

Comparative characterization of transfection- and infection-derived simian immunodeficiency virus challenge stocks for in vivo nonhuman primate studies.

Journal of virology - 1 Apr 2013

Del Prete Gregory Q, Scarlotta Matthew, Newman Laura, Reid Carolyn, Parodi Laura M, Roser James D, Oswald Kelli, Marx Preston A, Miller Christopher J, Desrosiers Ronald C, Barouch Dan H, Pal Ranajit, Piatak Michael, Chertova Elena, Giavedoni Luis D, O'Connor David H, Lifson Jeffrey D, Keele Brandon F

Abstract excerpt

Simian immunodeficiency virus (SIV) stocks for in vivo nonhuman primate models of AIDS are typically generated by transfection of 293T cells with molecularly cloned viral genomes or by expansion in productively infected T cells. Although titers of stocks are determined for infectivity in vitro prior to in vivo inoculation, virus production methods may differentially affect stock features that are not routinely...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23408608
DOI: 10.1128/JVI.03507-12
PMCID: PMC3624367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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