Article
Occupational toluene exposure induces cytochrome P450 2E1 mRNA expression in peripheral lymphocytes.
Environmental health perspectives - 1 Apr 2006
Mendoza-Cantú Ania, Castorena-Torres Fabiola, Bermúdez de León Mario, Cisneros Bulmaro, López-Carrillo Lizbeth, Rojas-García Aurora E, Aguilar-Salinas Alberto, Manno Maurizio, Albores Arnulfo
Abstract excerpt
Print workers are exposed to organic solvents, of which the systemic toxicant toluene is a main component. Toluene induces expression of cytochrome P450 2E1 (CYP2E1), an enzyme involved in its own metabolism and that of other protoxicants, including some procarcinogens. Therefore, we investigated the association between toluene exposure and the CYP2E1 response, as assessed by mRNA content in peripheral...
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