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Article

Ethanol Induces CYP2E1 by Protein Stabilization

1 Dec 1995

Abstract excerpt

In the present study, we demonstrate that ethanol induces CYP2E1 by protein stabilization in vivo. The control half-life of CYP2E1 was determined to be 6-7 h followed by a slower secondary phase. The half-life of ethanol-stabilized CYP2E1 was calculated to be 38 h. The mechanism underlying the rapid degradation of CYP2E1 was also investigated and appears to involve the ubiquitin-proteasome proteolytic pathway. An...

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PMID: 8530344
DOI: 10.1074/jbc.270.50.29632

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