Article
Long-term (imprinting) effects of transplacental treatment of mice with 3-methylcholanthrene or beta-naphthoflavone on hepatic metabolism of 3-methylcholanthrene.
Pharmacology & toxicology - 1 Sept 1991
Anderson L M, Jones A B, Riggs C W
Abstract excerpt
Foetal mice of genotype AhbAhd (responsive to induction of metabolism of polycyclic aromatic hydrocarbons [PAH]) or AhdAhd (non-responsive) were exposed transplacentally on gestation day 17 to a single dose of 3-methylcholanthrene (MC, 5-175 mg/kg) with or without prior treatment on day 15 with b...
Topics
- Animals
- Aryl Hydrocarbon Hydroxylases
- Benzoflavones
- Female
- Gene Expression Regulation
- Liver
- Longitudinal Studies
- Male
- Maternal-Fetal Exchange
- Methylcholanthrene
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Phenotype
- Pregnancy
- beta-Naphthoflavone