Article
A maternal Ahr null genotype sensitizes embryos to chemical teratogenesis.
The Journal of biological chemistry - 16 Jul 2004
Thomae Tami L, Glover Edward, Bradfield Christopher A
Abstract excerpt
The aryl hydrocarbon receptor (encoded by the Ahr locus) is a ligand-activated transcription factor that mediates the toxicology and teratology of 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). In an effort to understand the role of the maternal compartment in dioxin teratology, we designed a breeding strategy that allowed us to compare the teratogenic response in embryos from Ahr(-/-) (null) and Ahr(+/+)...
Topics
- Animals
- Chromatography
- Cleft Palate
- Dexamethasone
- Dioxins
- Dose-Response Relationship, Drug
- Female
- Genotype
- Hydronephrosis
- Male
- Mass Spectrometry
- Maternal Exposure
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mothers
- Pedigree
- Pregnancy