Article
A maternal Ahr null genotype sensitizes embryos to chemical teratogenesis.
The Journal of biological chemistry - 16 Jul 2004
Thomae Tami L, Glover Edward, Bradfield Christopher A
Abstract excerpt
The aryl hydrocarbon receptor (encoded by the Ahr locus) is a ligand-activated transcription factor that mediates the toxicology and teratology of 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). In an effort to understand the role of the maternal compartment in dioxin teratology, we designed a breeding strategy that allowed us to compare the teratogenic response in embryos from Ahr(-/-) (null) and Ahr(+/+)...
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