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Article

The importance of the 3' untranslated region for the expression of the alpha-globin genes.

Hemoglobin - 1 Feb 1996

Molchanova T P, Huisman T H

Abstract excerpt

With a reverse transcription-polymerase chain reaction procedure, we have determined the relative quantities of alpha 2- and alpha 1-mRNA in several patients with heterozygosities for alpha 2- or alpha 1-globin gene mutations, in subjects with two forms of alpha-thalassemia-2 (-3.7 kb; -4.2 kb), and in two children with an alpha-globin gene triplication. Mutations in either one of the two genes do not affect the...

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Identifiers

PMID: 8745431
DOI: 10.3109/03630269609027909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The importance of the 3' untranslated region for the expression of the alpha-globin genes.PMID 8745431Read ↗

Globin mRNA in beta-thalassemia heterozygotes with different beta-thalassemia alleles and in heterozygotes for hereditary persistence of fetal hemoglobin.Semantic proximity Read ↗

The differences in quantities of alpha 2- and alpha 1-globin gene variants in heterozygotes.Semantic proximity Read ↗

The alpha / beta and alpha 2 / alpha 1-globin mRNA ratios in different forms of alpha-thalassemia.Semantic proximity Read ↗

The delta-globin RNA transcript level in beta-thalassemia carriers.Semantic proximity Read ↗

Relative levels of alpha-, beta-, and gamma-mRNA from patients with severe and intermediate beta-thalassemia major.Semantic proximity Read ↗

Moderate reduction of beta-globin gene transcript by a novel mutation in the 5' untranslated region: a study of its interaction with other genotypes in two families.Semantic proximity Read ↗

The beta-globin C-->G mutation at 6 bp 3' to the termination codon causes beta-thalassaemia by decreasing the mRNA level.Semantic proximity Read ↗

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Alpha-thalassaemia caused by a polyadenylation signal mutation.Semantic proximity Read ↗

An anemic patient with phenotypical beta-thalassemic trait has elevated level of structurally normal beta-globin mRNA in reticulocytes.Semantic proximity Read ↗

Erythroid cell-specific mRNA stability elements in the alpha 2-globin 3' nontranslated region.Semantic proximity Read ↗

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