Article
The delta-globin RNA transcript level in beta-thalassemia carriers.
Acta haematologica - 1 Jan 1999
Huang S Z, Zeng F Y, Chen M J, Ren Z R, Shen M, Rodgers G P, Schechter A N, Zeng Y T
Abstract excerpt
Increased levels of hemoglobin A(2) (HbA(2)) are present in most beta-thalassemia carriers. The mechanism of this effect is not understood, although the increase may result from transcriptional and posttranscriptional changes. In the present study, we quantitate delta-globin mRNA levels in peripheral-blood-enriched reticulocytes and characterize the variation of delta-mRNA levels in 30 beta-thalassemia...
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