Article
Relative levels of alpha-, beta-, and gamma-mRNA from patients with severe and intermediate beta-thalassemia major.
Acta haematologica - 1 Jan 1997
Smetanina N S, Gu L H, Schilirò G, Di Cataldo A, Testa R, Jakovlevska Z, Efremov G D, Huisman T H
Abstract excerpt
We have determined the relative quantities of gamma- and beta-mRNAs and the alpha/beta-mRNA ratios in 37 patients with beta-thalassemia major with specific genotypes, namely 8 with a homozygosity for codon (CD) 39 (C-->T), 7 with a homozygosity for IVS-I-110 (G-->A), 5 with a homozygosity for IVS...
Topics
- Codon
- Gene Expression Regulation
- Genotype
- Globins
- Humans
- Point Mutation
- RNA, Messenger
- Severity of Illness Index
- beta-Thalassemia