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Article

Alpha-thalassaemia caused by a polyadenylation signal mutation.

Nature - 1 Jan 2000

Higgs D R, Goodbourn S E, Lamb J, Clegg J B, Weatherall D J, Proudfoot N J

Abstract excerpt

Most eukaryotic messenger RNAs have the sequence AAUAAA 11-30 nucleotides from the 3'-terminal poly(A) tract. Since this is the only significant sequence homology in the 3' non-coding region it has been suggested that it may be a recognition site for enzymes involved in polyadenylation and/or ter...

Topics

Base Sequence
Gene Expression Regulation
Globins
Humans
Mutation
Poly A
RNA Polymerase II
RNA, Messenger
Thalassemia
Transcription, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 6646217
DOI: 10.1038/306398a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-6646217-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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