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Article

Alpha-thalassaemia caused by a polyadenylation signal mutation.

Nature - 1 Jan 2000

Higgs D R, Goodbourn S E, Lamb J, Clegg J B, Weatherall D J, Proudfoot N J

Abstract excerpt

Most eukaryotic messenger RNAs have the sequence AAUAAA 11-30 nucleotides from the 3'-terminal poly(A) tract. Since this is the only significant sequence homology in the 3' non-coding region it has been suggested that it may be a recognition site for enzymes involved in polyadenylation and/or termination of polymerase II transcription. This idea is strengthened by observations on the effect of deletion mutations...

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PMID: 6646217
DOI: 10.1038/306398a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Alpha-thalassaemia caused by a polyadenylation signal mutation.PMID 6646217Read ↗

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