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Article

The differences in quantities of alpha 2- and alpha 1-globin gene variants in heterozygotes.

British journal of haematology - 1 Oct 1994

Molchanova T P, Pobedimskaya D D, Huisman T H

Abstract excerpt

We have identified through sequencing of amplified DNA the mutations in the alpha 2- and alpha 1-globin genes in 63 individuals with a heterozygosity for an alpha chain abnormal haemoglobin (Hb). Moreover, we developed a reverse transcription/polymerase chain reaction (RT/PCR) based procedure for the determination of the alpha 2- and alpha 1-mRNA ratio in normal individuals. The numbers of alpha 2 and alpha 1...

Topics

Base Sequence
Globins
Hemoglobins, Abnormal
Heterozygote
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
RNA, Messenger
alpha-Thalassemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7803274
DOI: 10.1111/j.1365-2141.1994.tb05022.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7803274-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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