Globin mRNA in beta-thalassemia heterozygotes with different beta-thalassemia alleles and in heterozygotes for hereditary persistence of fetal hemoglobin.

doi:10.1159/000203768

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Article

Globin mRNA in beta-thalassemia heterozygotes with different beta-thalassemia alleles and in heterozygotes for hereditary persistence of fetal hemoglobin.

Acta haematologica - 1 Jan 1996

Smetanina N S, Adekile A D, Huisman T H

Abstract excerpt

Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to determine the alpha 2/alpha 1-, alpha/beta-, and gamma/beta-mRNA ratios in subjects with beta-thalassemia (beta-thal), hereditary persistence of fetal hemoglobin (HPFH), and normal adults. The alpha- and beta-globin gene mutatio...

Topics

Adolescent
Adult
Alleles
Black People
Child
Child, Preschool
Female
Fetal Hemoglobin
Gene Expression
Globins
Heterozygote
Homozygote
Humans
Infant
Male
Middle Aged
Mutation
RNA, Messenger

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