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Article

The alpha / beta and alpha 2 / alpha 1-globin mRNA ratios in different forms of alpha-thalassemia.

Biochimica et biophysica acta - 12 Apr 1996

Smetanina N S, Leonova J Y, Levy N, Huisman T H

Abstract excerpt

The present study provides information about the alpha / beta and alpha 2 / alpha 1-mRNA ratios in reticulocytes of normal adults and individuals with different alpha-globin gene deficiencies; it found its origin in analytical data of blood samples from a Laotian couple and their newborn baby. The father carried the 4.2 kb deletion on one chromosome and a TAA --> CAA mutation at the terminating codon of the alpha...

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PMID: 8611658
DOI: 10.1016/0925-4439(95)00123-9

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TAT

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The alpha / beta and alpha 2 / alpha 1-globin mRNA ratios in different forms of alpha-thalassemia.PMID 8611658Read ↗

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The differences in quantities of alpha 2- and alpha 1-globin gene variants in heterozygotes.Semantic proximity Read ↗

The importance of the 3' untranslated region for the expression of the alpha-globin genes.Semantic proximity Read ↗

The delta-globin RNA transcript level in beta-thalassemia carriers.Semantic proximity Read ↗

Analysis of mRNA from red cells of patients with thalassemia and hemoglobin variants.Semantic proximity Read ↗

Relative levels of alpha-, beta-, and gamma-mRNA from patients with severe and intermediate beta-thalassemia major.Semantic proximity Read ↗

A novel polyadenylation signal mutation in the α<sub>2</sub>‐globin gene causing α thalassaemiaSemantic proximity Read ↗

Molecular basis for alpha-thalassemia associated with the structural mutant hemoglobin Suan-Dok (alpha 2 109leu----arg)Semantic proximity Read ↗

Quantities of alpha Q chain variants in heterozygotes with and without a concomitant beta-thalassemia trait.Semantic proximity Read ↗

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An anemic patient with phenotypical beta-thalassemic trait has elevated level of structurally normal beta-globin mRNA in reticulocytes.Semantic proximity Read ↗

Levels of Hb A2 in heterozygotes and homozygotes for beta-thalassemia mutations: influence of mutations in the CACCC and ATAAA motifs of the beta-globin gene promoter.Semantic proximity Read ↗

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