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Article

Automated determination of dextromethorphan and its main metabolites in human plasma by high-performance liquid chromatography and column switching.

Therapeutic drug monitoring - 1 Jun 1996

Härtter S, Baier D, Dingemanse J, Ziegler G, Hiemke C

Abstract excerpt

An automated column-switching technique coupled to isocratic high-performance liquid chromatography (HPLC) with fluorescence detection was developed for simultaneous determination of dextromethorphan and its three major metabolites, dextrorphan, hydroxymorphinan, and methoxymorphinan. After cleavage of conjugates by incubation with glucuronidasearylsulfatase at 37 degrees C for 15 h, plasma samples were injected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8738772
DOI: 10.1097/00007691-199606000-00014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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