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Article

Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity.

Journal of chromatography. B, Biomedical applications - 29 Mar 1996

Ducharme J, Abdullah S, Wainer I W

Abstract excerpt

Dextromethorphan (DM) is O-demethylated into dextrorphan (DEX) in humans by the cytochrome P450 designated as CYP2D6 and N-demethylated into 3-methoxymorphinan (3MM) via CYP3As. Clinically, DM has been successfully used as an index of CYP2D6 and this paper describes analytical and clinical data that will help evaluate the use of DM hydrobromide as a probe of CYP3A activity. DM and its three demethylated...

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Source

Identifiers

PMID: 8861661
DOI: 10.1016/0378-4347(95)00574-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity.PMID 8861661Read ↗

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