Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity.

doi:10.1016/0378-4347(95)00574-9

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Article

Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity.

Journal of chromatography. B, Biomedical applications - 29 Mar 1996

Ducharme J, Abdullah S, Wainer I W

Abstract excerpt

Dextromethorphan (DM) is O-demethylated into dextrorphan (DEX) in humans by the cytochrome P450 designated as CYP2D6 and N-demethylated into 3-methoxymorphinan (3MM) via CYP3As. Clinically, DM has been successfully used as an index of CYP2D6 and this paper describes analytical and clinical data t...

Topics

Adult
Antineoplastic Agents, Phytogenic
Aryl Hydrocarbon Hydroxylases
Brain Neoplasms
Chromatography, High Pressure Liquid
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System
Dextromethorphan
Female
Glioma
Humans
Male
Middle Aged
Molecular Probes
Oxidoreductases, N-Demethylating
Phenotype
Reproducibility of Results

Source

Open in PubMed

Identifiers

PMID: 8861661
DOI: 10.1016/0378-4347(95)00574-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8861661-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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