Article
Human apolipoprotein B signal sequence variants confer a secretion-defective phenotype when expressed in yeast.
The Journal of biological chemistry - 26 Aug 1994
Sturley S L, Talmud P J, Brasseur R, Culbertson M R, Humphries S E, Attie A D
Abstract excerpt
Hyperlipidemia arises from a disturbance in the balance between production and degradation of lipoprotein particles. Variation in the secretion of human apolipoprotein B (apoB), the major protein component of triglyceride-rich lipoproteins, directly affects this homeostasis. Naturally occurring a...
Topics
- Amino Acid Sequence
- Apolipoproteins B
- Base Sequence
- Biological Transport, Active
- Cell Compartmentation
- Genetic Variation
- Glycoside Hydrolases
- Humans
- Molecular Sequence Data
- Phenotype
- Protein Sorting Signals
- Recombinant Fusion Proteins
- Recombinant Proteins
- Saccharomyces cerevisiae
- beta-Fructofuranosidase