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Article

Human apolipoprotein B signal sequence variants confer a secretion-defective phenotype when expressed in yeast.

The Journal of biological chemistry - 26 Aug 1994

Sturley S L, Talmud P J, Brasseur R, Culbertson M R, Humphries S E, Attie A D

Abstract excerpt

Hyperlipidemia arises from a disturbance in the balance between production and degradation of lipoprotein particles. Variation in the secretion of human apolipoprotein B (apoB), the major protein component of triglyceride-rich lipoproteins, directly affects this homeostasis. Naturally occurring apoB signal peptide variants (associated with hypertriglyceridemia, altered postprandial lipid metabolism, or...

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PMID: 8063810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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