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Article

Disease mutations reveal residues critical to the interaction of P4-ATPases with lipid substrates.

Scientific reports - 5 Sept 2017

Gantzel Rasmus H, Mogensen Louise S, Mikkelsen Stine A, Vilsen Bente, Molday Robert S, Vestergaard Anna L, Andersen Jens P

Abstract excerpt

Phospholipid flippases (P4-ATPases) translocate specific phospholipids from the exoplasmic to the cytoplasmic leaflet of membranes. While there is good evidence that the overall molecular structure of flippases is similar to that of P-type ATPase ion-pumps, the transport pathway for the "giant" lipid substrate has not been determined. ATP8A2 is a flippase with selectivity toward phosphatidylserine (PS),...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 28874751
DOI: 10.1038/s41598-017-10741-z
PMCID: PMC5585164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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