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Article

Role of the lid hydrophobicity pattern in pancreatic lipase activity.

The Journal of biological chemistry - 2 Dec 2005

Thomas Annick, Allouche Maya, Basyn Frédéric, Brasseur Robert, Kerfelec Brigitte

Abstract excerpt

Pancreatic lipase is a soluble globular protein that must undergo structural modifications before it can hydrolyze oil droplets coated with bile salts. The binding of colipase and movement of the lipase lid open access to the active site. Mechanisms triggering lid mobility are unclear. The *KNILSQIVDIDGI* fragment of the lid of the human pancreatic lipase is predicted by molecular modeling to be a tilted peptide....

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Identifiers

PMID: 16179352
DOI: 10.1074/jbc.M502123200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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