Article
Proteolipid/DM-20 proteins bearing the paralytic tremor mutation in peripheral nerves and transfected Cos-7 cells.
Neurochemical research - 1 Apr 1996
Tosic M, Gow A, Dolivo M, Domanska-Janik K, Lazzarini R A, Matthieu J M
Abstract excerpt
Paralytic tremor (Plp-pt) is a missense mutation of the myelin proteolipid gene (Plp) in rabbits. The myelin yield in the Plp-pt brain is reduced and the protein and lipid composition of central nervous system (CNS) myelin is abnormal. We studied the intracellular transport of the normal and Plp-...
Topics
- Animals
- Brain Chemistry
- Cell Line
- DNA, Complementary
- Fluorescent Antibody Technique, Indirect
- Mutation
- Myelin Basic Protein
- Myelin Proteolipid Protein
- Rabbits
- Sciatic Nerve
- Transfection
- Tremor