Article
pt point mutation in plp gene results in hyperexpression of MOG in hypomyelinated rabbit.
Acta neurobiologiae experimentalis - 1 Jan 1996
Sypecka J
Abstract excerpt
Myelin/oligodendrocyte glycoprotein (MOG) is a minor myelin protein that belongs to the immunoglobulin gene superfamily and evokes demyelination based on immunological response. Localized preferentially at the external surfaces of myelin sheaths, it is one of the primarily target autoantigens in experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. Elevated MOG content has been...
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